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Allopurinol in dermatology.
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Off-label use is common in dermatology and is inevitable for rare cutaneous diseases such as perforating dermatosis. Allopurinol is traditionally considered to be a drug for hyperuricemia only but th

Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population.
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The contribution of the human leukocyte antigen (HLA) subtype to slow-onset type 1 diabetes (T1D) which includes latent autoimmune diabetes in adults (LADA) remains unclear in the Japanese population

Specific "intra-allele" and "intra-broad antigen" human leukocyte antigen alloantibodies in kidney graft transplantation.
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Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with id

Comparison of allele frequency for HLA-DR and HLA-DQ between patients with ECC and caries free children
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Background: Early childhood caries (ECC) is one of the most common diseases of childhood. Etiology of ECC is multifactorial and both genetic and environmental factors play important roles in the path

Trans-species polymorphism, HLA-disease associations and the evolution of the MHC
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Currently, the paradigm is that Major Histocompatibility Complex (MHC) polymorphism is maintained by balancing selection on the immune genes. However, other evolutionary forces besides selection also