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Automated segmentation of the macula by optical coherence tomography
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This paper presents optical coherence tomography (OCT) signal intensity variation based segmentation algorithms for retinal layer identification. Its main ambition is to reduce the calculation time r

Redesigning digital dictation for physicians: A user-centred approach
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The user-centred approach has proven its success in software and product development. However, in the healthcare domain, user-centred research methodology has been applied less widely. This article r

Antiproliferative Activity Against MCF-7 Breast Cancer Cells by Diamino-Triazaspirodiene Antifolates
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Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian DHFR inhibitors; one having a 6,5-spiro bicyclic ring system (IC50 = 2.3 nM) and the other a 6,

Director of Stroke Research, University of Minnesota Stroke Center
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The objective of this study was to assess the effect of flow diversion by external carotid artery (ECA) occlusion on ipsilateral regional cerebral blood flow (rCBF). Local cerebral hyperperfusion i

MEFV heterogeneity in Turkish Familial Mediterranean Fever
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Turkey is one of the few countries in the world where Familial Mediterranean Fever (FMF), an autoinflammatory disease caused by mutations in MEFV, the gene encoding pyrin, is not rare. Many intere

MEFV heterogeneity in Turkish Familial Mediterranean Fever
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Turkey is one of the few countries in the world where Familial Mediterranean Fever (FMF), an autoinflammatory disease caused by mutations in MEFV, the gene encoding pyrin, is not rare. Many intere

Augmenting Cerebral Perfusion and Tissue Oxygenation due to Occlusion of External Carotid Artery
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Objective: The objective of this study was to assess the effect of flow diversion by external carotid artery (ECA) occlusion on ipsilateral regional cerebral blood flow (rCBF). Design: Local ce

Development of a methodological search filter for finding studies on measurement properties of outcome measures in PubMed
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Objectives For the measurement of patient-reported outcomes, such as (health-related) quality of life, often many measurement instruments exist that intend to measure the same construct. To facilitat

Analysis of central blood pressure during diphtheria intoxication in rabbits
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Diphtheria intoxication was induced in rabbits by a single intravenous injection of native diphtheria toxin in dose of 0.3 MLD/kg, preliminary titrated on guinea pigs. Significant decrease in diastol

Developmental links between adolescent disclosure, parental solicitation, parental control and adolescent delinquency. Moderation by parental support.
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This 4-wave study among 309 Dutch adolescents and their parents examined changes in adolescent disclosure, parental solicitation, and parental control and their links with the development of delinque
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