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Powerpoint Slides tags by : DHFR inhibitors
 

Antiproliferative Activity Against MCF-7 Breast Cancer Cells by Diamino-Triazaspirodiene Antifolates
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Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian DHFR inhibitors; one having a 6,5-spiro bicyclic ring system (IC50 = 2.3 nM) and the other a 6,