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| Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian DHFR inhibitors; one having a 6,5-spiro bicyclic ring system (IC50 = 2.3 nM) and the other a 6, |
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| Standard treatment with heparin followed by vitamin K antagonists is frequently complicated by bleeding and recurrent venous thromboembolism (VTE) in cancer patients with VTE. To compare the efficacy |
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| In recent years molecular-targeted agents have been used clinically to treat various malignant tumors. In May 2009 sorafenib (Nexavar) was approved in Japan for "unresectable hepatocellular carcinoma |
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| Anemia in elderly patients should never be regarded as a normal physiological response to aging. The main categories of anemia in older patients are the nutritional anemia attributed to iron deficien |
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| After iron deficiency anemia the anemia of chronic disorder is the second most frequent anemia and in hospitalized patients and/or patients suffering from chronic disease especially infection cancer |
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| Rapid diagnosis of sepsis is of outstanding significance as each hour of delay of appropriate antimicrobial therapy increases mortality by 5-10. As a result antibiotics are started without a definiti |
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| The zinc finger transcription factor ZNF24 is a relatively uncharacterized Krüppel-like transcription factor displaying a suppressive effect on the transcription. ZNF24 is involved in negative regula |
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| The epidermal growth factor receptor (EGFR) is a key driver in the process of squamous cell carcinoma (SCC) cell mitogenesis. Phospholipase C-gamma1 (PLC-gamma1) is a downstream target of EGFR signal |
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| Fine-needle aspiration (FNA) is the crucial diagnostic test used for the evaluation of patients with a thyroid nodule. The result of an FNA determines if a patient can be followed with repeated exami |
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| The surgical management of thyroid disease and its indications continue to evolve. Selecting the appropriate management can often be challenging to both physician and patient. This article describes |
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