Abstract : Ultrafast 2D NMR allows the acquisition of a 2D spectrum in a single scan. Still a limitation affec
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Abstract : Ultrafast 2D NMR allows the acquisition of a 2D spectrum in a single scan. Still a limitation affecting these experiments rests in their inability to cover large spectral ranges while preserving an acceptable resolution due to limitations in gradient amplitudes and filter bandwidths. Various approaches relying on selective pulses have been recently proposed to overcome this drawback by "shifting" resonances into arbitrary positions. However these methods are associated with a number of drawbacks characterizing selective pulses. Here we propose a new strategy to increase the spectral width accessible in the ultrafast dimension without degrading the resolution. This method leads to "folded-like" spectra along the ultrafast dimension. It does not require any selective pulse and relies on suitably chosen gradients placed on each side of the mixing period. Our gradient-controlled folding method can be applied to almost any ultrafast 2D experiment and appears to be particularly promising for heteronuclear 2D NMR. The results obtained on different compounds and pulse sequences (DQF-COSY TOCSY HSQC) are presented highlighting the efficiency and the robustness of our method.Copyright (c) 2010 Elsevier Inc. All rights reserved.PMID 20510639 PubMed - indexed for MEDLINEMeSH Terms SubstancesMeSH TermsAlgorithmsElectromagnetic FieldsIbuprofen/chemistryIsomerismMagnetic Resonance Spectroscopy/methods*Molecular ConformationMonoterpenes/chemistrySubstancesMonoterpenesIbuprofencitralLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesMolecular Biology DatabasesIBUPROFEN - HSDBCITRAL - HSDB Supplemental Content Related citations Multiple ultrafast broadband 2D NMR spectra of hyperpolarized natural products. J Am Chem Soc. 2009 Multiple ultrafast broadband 2D NMR spectra of hyperpolarized natural products.Giraudeau P Shrot Y Frydman L. J Am Chem Soc. 2009 Oct 7 131(39)13902-3. Spatial/spectral encoding of the spin interactions in ultrafast multidimensional NMR. J Chem Phys. 2009 Spatial/spectral encoding of the spin interactions in ultrafast multidimensional NMR.Shrot Y Frydman L. J Chem Phys. 2009 Dec 14 131(22)224516. Ultrafast 2D COSY with constant-time phase-modulated spatial encoding. J Magn Reson. 2010 Ultrafast 2D COSY with constant-time phase-modulated spatial encoding.Wu C Zhao M Cai S Lin Y Chen Z. J Magn Reson. 2010 May 204(1)82-90. Epub 2010 Feb 12. Review In vivo 2D magnetic resonance spectroscopy of small animals. MAGMA. 2004 Review In vivo 2D magnetic resonance spectroscopy of small animals.Méric P Autret G Doan BT Gillet B Sébrié C Beloeil JC. MAGMA. 2004 Dec 17(3-6)317-38. Epub 2004 Dec 29. Review Resonance assignment strategies for the analysis of NMR spectra of proteins. Mol Biotechnol. 1994 Review Resonance assignment strategies for the analysis of NMR spectra of proteins.Leopold MF Urbauer JL Wand AJ. Mol Biotechnol. 1994 Aug 2(1)61-93. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On A new gradient-controlled method for improving the spectral width of ultrafast 2... A new gradient-controlled method for improving the spectral width of ultrafast 2D NMR experiments.J Magn Reson. 2010 Jul 205(1)171-6. Epub 2010 May 10 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
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