Abstract : The concept of an alternative pathway of macrophage activation has stimulated interest in its defin
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Abstract : The concept of an alternative pathway of macrophage activation has stimulated interest in its definition mechanism and functional significance in homeostasis and disease. We assess recent research in this field argue for a restricted definition and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology their biosynthesis and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20510870 PubMed - indexed for MEDLINEPublication Types MeSH Terms Substances Grant SupportPublication Types Research Support Non-U.S. GovtReviewMeSH TermsAnimalsCytokines/immunologyHumansMacrophage Activation/drug effectsMacrophage Activation/immunology*Macrophages/immunology*Macrophages/metabolismModels BiologicalNeoplasms/immunologyNeoplasms/physiopathology*Receptors Interleukin/immunologySignal TransductionSubstancesCytokinesReceptors InterleukinGrant SupportBritish Heart Foundation/United KingdomLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesOther Literature SourcesCOS Scholar UniverseMedicalCancer - MedlinePlus Health Information Supplemental Content Related citations Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J. 2008 Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.Donnelly S Stack CM ONeill SM Sayed AA Williams DL Dalton JP. FASEB J. 2008 Nov 22(11)4022-32. Epub 2008 Aug 15. Review Alternative activation of macrophages an immunologic functional perspective. Annu Rev Immunol. 2009 Review Alternative activation of macrophages an immunologic functional perspective.Martinez FO Helming L Gordon S. Annu Rev Immunol. 2009 27451-83. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest. 2006 The IL-21 receptor augments Th2 effector function and alternative macrophage activation.Pesce J Kaviratne M Ramalingam TR Thompson RW Urban JF Jr Cheever AW Young DA Collins M Grusby MJ Wynn TA. J Clin Invest. 2006 Jul 116(7)2044-55. Epub 2006 Jun 15. Review Alternative activation of macrophages. Nat Rev Immunol. 2003 Review Alternative activation of macrophages.Gordon S. Nat Rev Immunol. 2003 Jan 3(1)23-35. Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages which suppress T-cell responses. Blood. 2002 Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages which suppress T-cell responses.Tzachanis D Berezovskaya A Nadler LM Boussiotis VA. Blood. 2002 Feb 15 99(4)1465-73. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Cited in PMC Full-text articles in the PubMed Central Database that cite the current articles. Recent activity Clear Turn Off Turn On Alternative activation of macrophages mechanism and functions. Alternative activation of macrophages mechanism and functions.Immunity. 2010 May 28 32(5)593-604. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
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