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Tags : diphthteria intoxication   central blood pressure   pulse wave  more

Tags : diphthteria intoxication   central blood pressure   pulse wave   arterial stiffness   left vetricle  less

Reference : 1. Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms // Am. J    more

Reference : 1. Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms // Am. J. Hypertens. 2005 Jan; 18 (1 Pt 2): 3S-10S 2. Haemodynamic basis for the development of left ventricular failure in systolic hypertension and for its logical therapy // J. Hypertens. 1995 Sep; 13 (9): 943-952. 3. Gender specific brachial artery blood pressure-independent relationship between pulse wave velocity and left ventricular mass index in a group of African ancestry // J. hypertens. 2008 Aug; 26(8): 1619-1628. 4. Arterial elastance and wve reflection augmentation of systolic blood pressure: deleterious effect and implications for therapy // J. Cardiovasc. Pharmacol. Ther. 2001 Jan; 6(1): 5-21. 5. Ageing and wave reflaction // J. Hypertens. Suppl.. 1992 Aug; 10(6): S83-S86.    less

Abstract : Diphtheria intoxication was induced in rabbits by a single intravenous injection of native diphther    more

Abstract : Diphtheria intoxication was induced in rabbits by a single intravenous injection of native diphtheria toxin in dose of 0.3 MLD/kg, preliminary titrated on guinea pigs. Significant decrease in diastolic and systolic blood pressure and in intraventricular pressure in the left ventricle was established to take place during intoxication. Pulse wave propagation time was prolonged, likely due to prolongation of pressure wave, while the reflection wave appeared at the same time. Reduction of central blood pressure was concluded to result from changes in biomechanical characteristics of the left ventricle, and not to be associated with changes in elastic properties of the arterial wall.- Slides    less