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Tags : DHFR inhibitors   antiproliferative acitivty   1  more

Tags : DHFR inhibitors   antiproliferative acitivty   1  3  5-triazines  less

Reference : Chemical Biology & Drug Design, 2009, 74, 322-326.

Abstract : Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mamma    more

Abstract : Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian DHFR inhibitors; one having a 6,5-spiro bicyclic ring system (IC50 = 2.3 nM) and the other a 6,6-spiro bicyclic system (IC50 = 6.9 nM). They also showed more than 50% antiproliferative activity against the MCF-7 breast cancer cells at 20µM. This study demonstrated the potential lead of the diamino triazaspirodienes in anticancer chemotherapeutical agents’ development.- Slides    less