Abstract : The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidat
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Abstract : The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation ultraviolet (UV) light-induced conformational changes heat-induced conformational changes and attacks by free radicals. Vitamin D(2) is much less bioactive than vitamin D(3) in humans. Metabolic activation and inactivation of vitamin D are well characterized and result in a plethora of metabolites of which only 25-hydroxyvitamin D (25(OH)D) and 125-dihydroxyvitamin D (125(OH)(2)D) provide any clinically relevant information. 25(OH)D(2) and 25(OH)D(3) are commonly known as calcifediol and the 125(OH)(2)D metabolites as calcitriol. In this review the current state of the science on the clinical assessment of circulating 25(OH)D and 125(OH)(2)D is described.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20511051 PubMed - indexed for MEDLINEPMCID PMC2903449 Available on 2011/6/1Publication Types MeSH Terms Substances Grant SupportPublication Types ReviewMeSH TermsBinding CompetitiveFemaleHumansNutritional RequirementsRadioimmunoassay/standardsRadioligand Assay/standardsVitamin D/analogs amp derivatives*Vitamin D/bloodVitamin D/chemistryVitamin D/metabolismSubstancesVitamin D25-hydroxyvitamin D125-dihydroxyvitamin DGrant SupportR01 HD047511-04/HD/NICHD NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceW.B. SaundersMD ConsultOther Literature SourcesCOS Scholar UniverseMedicalVitamin D - MedlinePlus Health Information Supplemental Content Related citations Review Measuring 25-hydroxyvitamin D in a clinical environment challenges and needs. Am J Clin Nutr. 2008 Review Measuring 25-hydroxyvitamin D in a clinical environment challenges and needs.Hollis BW. Am J Clin Nutr. 2008 Aug 88(2)507S-510S. Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha 25-dihydroxyvitamin D2/D3. J Clin Invest. 1976 Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha 25-dihydroxyvitamin D2/D3.Hughes MR Baylink DJ Jones PG Haussler MR. J Clin Invest. 1976 Jul 58(1)61-70. Review Vitamin D status measurement interpretation and clinical application. Ann Epidemiol. 2009 Review Vitamin D status measurement interpretation and clinical application.Holick MF. Ann Epidemiol. 2009 Feb 19(2)73-8. Epub 2008 Mar 10. Roles of the structure and orientation of ligands and ligand mimics inside the ligand-binding pocket of the vitamin D-binding protein. Biochemistry. 1997 Roles of the structure and orientation of ligands and ligand mimics inside the ligand-binding pocket of the vitamin D-binding protein.Swamy N Dutta A Ray R. Biochemistry. 1997 Jun 17 36(24)7432-6. Review Expanding role for vitamin D in chronic kidney disease importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha25-dihydroxyvitamin D(3). Semin Dial. 2007 Review Expanding role for vitamin D in chronic kidney disease importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha25-dihydroxyvitamin D(3).Jones G. Semin Dial. 2007 Jul-Aug 20(4)316-24. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Assessment and interpretation of circulating 25-hydroxyvitamin D and 125-dihydr... Assessment and interpretation of circulating 25-hydroxyvitamin D and 125-dihydroxyvitamin D in the clinical environment.Endocrinol Metab Clin North Am. 2010 Jun 39(2)271-86 table of contents. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
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