Abstract : Autism spectrum disorders (ASD) and epilepsy co-occur in approximately 30 of individuals with eithe
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Abstract : Autism spectrum disorders (ASD) and epilepsy co-occur in approximately 30 of individuals with either ASD or epilepsy. While there is no single unifying ASD-epilepsy phenotype understanding potential commonalities in subgroups of children with an ASD-epilepsy phenotype will help us disentangle the pathophysiology of both ASD and epilepsy. Throughout this brief historical perspective we selectively review critical trends in ASD-epilepsy research and highlight challenges to clinical and research efforts including terminology heterogeneity of both ASD and epilepsy and lack of careful characterization of children affected with both ASD and epilepsy. These complex issues continue to burden research on the diagnosis neurobiology and management of children with ASD and epilepsy. A key concept that has emerged during the past 40 years is the strong association between intellectual disability and a higher prevalence of epilepsy in individuals with ASD. In addition the two peaks of seizure onset one in early childhood and one in adolescence and continuing through adulthood may be unique to individuals with ASD. The overlap of language and autistic regression to epilepsy EEG epileptiform activity sleep and to epileptic encephalopathies such as Landau-Kleffner syndrome continue to be controversial areas of research and of clinical interest. An emerging consensus is that shared developmental genetic molecular and pathophysiological mechanisms exist and account for the common co-occurrence of ASD and epilepsy.Copyright © 2010 Elsevier B.V. All rights reserved.PMID 20510557 PubMed - indexed for MEDLINEPublication Types MeSH TermsPublication Types Historical ArticleReviewMeSH TermsAutistic Disorder/history*Electroencephalography/methodsEpilepsy/history*History 20th CenturyHistory 21st CenturyHumansLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesMedicalEpilepsy - MedlinePlus Health InformationAutism - MedlinePlus Health Information Supplemental Content Related citations Magnetoencephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders. Pediatrics. 1999 Magnetoencephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders.Lewine JD Andrews R Chez M Patil AA Devinsky O Smith M Kanner A Davis JT Funke M Jones G et al. Pediatrics. 1999 Sep 104(3 Pt 1)405-18. Review The genetics of autism. Pediatrics. 2004 Review The genetics of autism.Muhle R Trentacoste SV Rapin I. Pediatrics. 2004 May 113(5)e472-86. Autism Spectrum Disorders GeneReviews. 1993 Autism Spectrum DisordersMiles JH McCathren RB Stichter J Shinawi M. GeneReviews. 1993 Review Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome LKS) and regressive autistic disorders with epileptic EEG abnormalities the continuing debate. Brain Dev. 2010 Review Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome LKS) and regressive autistic disorders with epileptic EEG abnormalities the continuing debate.Deonna T Roulet-Perez E. Brain Dev. 2010 Oct 32(9)746-52. Epub 2010 Jul 15. Review Measles-mumps-rubella vaccine and autistic spectrum disorder report from the New Challenges in Childhood Immunizations Conference convened in Oak Brook Illinois June 12-13 2000. Pediatrics. 2001 Review Measles-mumps-rubella vaccine and autistic spectrum disorder report from the New Challenges in Childhood Immunizations Conference convened in Oak Brook Illinois June 12-13 2000.Halsey NA Hyman SL Conference Writing Panel. Pediatrics. 2001 May 107(5)E84. See reviews... See all... Recent activity Clear Turn Off Turn On Autism and epilepsy historical perspective. Autism and epilepsy historical perspective.Brain Dev. 2010 Oct 32(9)709-18. Epub 2010 May 26 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
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