Abstract : Self-report and behavioral data suggest that impulsivity may contribute to the development and main
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Abstract : Self-report and behavioral data suggest that impulsivity may contribute to the development and maintenance of obesity. Neuroimaging studies implicate a widespread neural network in inhibitory control and suggest that impulsive individuals show hypoactivity in these regions during tasks requiring response inhibition. Yet research has not directly tested whether body mass correlates inversely with activation of these regions during response inhibition tasks. The present study used functional magnetic resonance imaging (fMRI) to investigate neural activations during a food-specific go/no-go task in adolescent girls ranging from lean to obese. When required to inhibit prepotent responses to appetizing food body mass index (BMI) correlated with response inhibition at both the behavioral and neural levels with more overweight adolescents showing greater behavioral evidence of impulsivity as well as reduced activation of frontal inhibitory regions including superior frontal gyrus middle frontal gyrus ventrolateral prefrontal cortex medial prefrontal cortex and orbitofrontal cortex than leaner individuals. As well activation in food reward regions (e.g. temporal operculum/insula) in response to food images correlated positively with BMI. Results suggest that hypofunctioning of inhibitory control regions and increased response of food reward regions are related to elevated weight.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20510377 PubMed - indexed for MEDLINEPMCID PMC2910204 Available on 2011/10/1MeSH Terms Grant SupportMeSH TermsAdolescentBody Mass IndexBody Weight/physiology*Brain/physiology*Feeding BehaviorFemaleHumansMagnetic Resonance Imaging*Neural Inhibition/physiology*Statistics as TopicGrant SupportR01 MH064560-01A1/MH/NIMH NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOSwets Information ServicesMedicalMRI Scans - MedlinePlus Health InformationBody Weight - MedlinePlus Health Information Supplemental Content Related citations Relation of reward from food intake and anticipated food intake to obesity a functional magnetic resonance imaging study. J Abnorm Psychol. 2008 Relation of reward from food intake and anticipated food intake to obesity a functional magnetic resonance imaging study.Stice E Spoor S Bohon C Veldhuizen MG Small DM. J Abnorm Psychol. 2008 Nov 117(4)924-35. Reward circuitry responsivity to food predicts future increases in body mass moderating effects of DRD2 and DRD4. Neuroimage. 2010 Reward circuitry responsivity to food predicts future increases in body mass moderating effects of DRD2 and DRD4.Stice E Yokum S Bohon C Marti N Smolen A. Neuroimage. 2010 May 1 50(4)1618-25. Epub 2010 Jan 29. Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity (Silver Spring). 2006 Neural mechanisms underlying hyperphagia in Prader-Willi syndrome.Holsen LM Zarcone JR Brooks WM Butler MG Thompson TI Ahluwalia JS Nollen NL Savage CR. Obesity (Silver Spring). 2006 Jun 14(6)1028-37. Review Relation of obesity to consummatory and anticipatory food reward. Physiol Behav. 2009 Review Relation of obesity to consummatory and anticipatory food reward.Stice E Spoor S Ng J Zald DH. Physiol Behav. 2009 Jul 14 97(5)551-60. Epub 2009 Mar 27. Review Structural and functional neuroanatomy of attention-deficit hyperactivity disorder (ADHD). Encephale. 2009 Review Structural and functional neuroanatomy of attention-deficit hyperactivity disorder (ADHD).Emond V Joyal C Poissant H. Encephale. 2009 Apr 35(2)107-14. Epub 2008 Jul 7. See reviews... See all... Recent activity Clear Turn Off Turn On Body mass correlates inversely with inhibitory control in response to food among... Body mass correlates inversely with inhibitory control in response to food among adolescent girls an fMRI study.Neuroimage. 2010 Oct 1 52(4)1696-703. Epub 2010 May 25 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
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