Abstract : The nephroprotective effect of coenzyme Q10 was investigated in mice with acute renal injury induce
more
Abstract : The nephroprotective effect of coenzyme Q10 was investigated in mice with acute renal injury induced by a single i.p. injection of cisplatin (5 mg/kg). Coenzyme Q10 treatment (10 mg/kg/day i.p.) was applied for 6 consecutive days starting 1 day before cisplatin administration. Coenzyme Q10 significantly reduced blood urea nitrogen and serum creatinine levels which were increased by cisplatin. Coenzyme Q10 significantly compensated deficits in the antioxidant defense mechanisms (reduced glutathione level and superoxide dismutase activity) suppressed lipid peroxidation decreased the elevations of tumor necrosis factor-alpha nitric oxide and platinum ion concentration and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administration. Also histopathological renal tissue damage mediated by cisplatin was ameliorated by coenzyme Q10 treatment. Immunohistochemical analysis revealed that coenzyme Q10 significantly decreased the cisplatin-induced overexpression of inducible nitric oxide synthase nuclear factor-kappaB caspase-3 and p53 in renal tissue. It was concluded that coenzyme Q10 represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice.2010 Elsevier Ireland Ltd. All rights reserved.PMID 20510337 PubMed - indexed for MEDLINEMeSH Terms SubstancesMeSH TermsAcute Kidney Injury/chemically induced*Acute Kidney Injury/metabolismAcute Kidney Injury/pathologyAnimalsAntioxidants/administration amp dosageAntioxidants/metabolismAntioxidants/pharmacologyBlood Urea NitrogenCaspase 3/metabolismCisplatin/adverse effects*Cisplatin/metabolismCisplatin/pharmacologyCreatinine/bloodCreatinine/metabolismCreatinine/pharmacologyGlutathione/adverse effectsGlutathione/metabolismGlutathione/pharmacologyKidney/drug effects*Lipid Peroxidation/drug effectsMaleMiceNitric Oxide/adverse effectsNitric Oxide/metabolismNitric Oxide/pharmacologyTumor Necrosis Factor-alpha/adverse effectsTumor Necrosis Factor-alpha/metabolismTumor Necrosis Factor-alpha/pharmacologyUbiquinone/adverse effectsUbiquinone/analogs amp derivativesUbiquinone/metabolismUbiquinone/pharmacologyUrea/bloodUrea/metabolismUrea/pharmacologySubstancesAntioxidantsTumor Necrosis Factor-alphaNitric OxideUbiquinoneCisplatincoenzyme Q10ubiquinol-10UreaCreatinineGlutathioneCaspase 3LinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesMolecular Biology DatabasesPLATINUM COMPOUNDS - HSDBCIS-DIAMINEDICHLOROPLATINUM - HSDBNITRIC OXIDE - HSDBUREA - HSDB Supplemental Content Related citations Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury. Pharmacology. 2010 Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury.Fouad AA Qureshi HA Al-Sultan AI Yacoubi MT Al-Melhim WN. Pharmacology. 2010 85(3)158-67. Epub 2010 Feb 11. Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity role of nitric oxide. Basic Clin Pharmacol Toxicol. 2005 Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity role of nitric oxide.Saleh S El-Demerdash E. Basic Clin Pharmacol Toxicol. 2005 Aug 97(2)91-7. 6-Gingerol prevents cisplatin-induced acute renal failure in rats. Biofactors. 2006 6-Gingerol prevents cisplatin-induced acute renal failure in rats.Kuhad A Tirkey N Pilkhwal S Chopra K. Biofactors. 2006 26(3)189-200. Cisplatin induces acute renal failure by impairing antioxidant system in guinea pigs effects of antioxidant supplementation on the cisplatin nephrotoxicity. Drug Chem Toxicol. 2002 Cisplatin induces acute renal failure by impairing antioxidant system in guinea pigs effects of antioxidant supplementation on the cisplatin nephrotoxicity.Durak I Ozbek H Karaayvaz M Oztürk HS. Drug Chem Toxicol. 2002 Feb 25(1)1-8. Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity. Ren Fail. 2007 Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity.Aydinoz S Uzun G Cermik H Atasoyu EM Yildiz S Karagoz B Evrenkaya R. Ren Fail. 2007 29(3)257-63. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.Toxicology. 2010 Jul-Aug 274(1-3)49-56. Epub 2010 May 25 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
less