Abstract : Since the 20th century, dengue fever became one of the leading causes of morbidity and mortality in
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Abstract : Since the 20th century, dengue fever became one of the leading causes of morbidity and mortality in tropical areas. Dengue virus is a mosquito-borne virus transmitted by Aedes mosquitoes. There are four distinct serological types. According to the World Health Organization, a person infected by the four dengue viruses goes through a spectrum of illness ranging from classical dengue fever, a self-limiting illness characterised by high temperature, headache, myalgia, arthralgia to a more severe form, dengue haemorrhage fever. For over 40 years, the pathogenesis of dengue was attributed to the presence of enhancing antibodies that are acquired during a primary infection and lead to an increase of infected cells, thereby an increase in viraemia, during secondary infections. This hypothesis is termed « antibody-dependent enhancement » (ADE). Although extensively studied, the role of ADE in the pathogenesis of dengue remains still unverified. We need to transcend the ADE theory in order to progress in dengue fever knowledge: a lot of facts demonstrate that dengue is logically close to yellow fever and it is time to carry out a meta-analysis to assess the validity of the ADE theory.- Slides
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