Abstract : Intestinal inflammation and inflammatory bowel diseases (IBD) may occur due to imbalances in pro- a
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Abstract : Intestinal inflammation and inflammatory bowel diseases (IBD) may occur due to imbalances in pro- and anti-inflammatory cytokines. Long-term exercise reduces the risk for IBD. The purpose of this study was to determine the effect of long-term wheel running in healthy mice on intestinal lymphocyte (IL) expression of pro- and anti-inflammatory cytokine proteins. In addition pro- and anti-apoptotic proteins and the percentage of early apoptotic late apoptotic and dead IL were measured with wheel running and following acute aerobic exercise. Female C57BL/6 mice were given 16 weeks of wheel running (WR) or a control condition (No WR) and at the end of training were assigned to a single acute treadmill exercise session with sacrifice immediately 2h after or 24h after completion of exercise or were not run (sedentary) with respect to the acute treadmill exercise. Intestinal lymphocytes were assessed for pro-(TNF-a IL-17) and anti-(IL-10) inflammatory and pleiotropic (IL-6) cytokines and pro-(caspase 3 and 7 AIF) and anti-(Bcl-2) apoptotic protein expression. The percent of early (Annexin(+)) and late (Annexin(+)PI(+)) apoptotic and dead (PI(+)) IL was determined. WR mice had lower TNF-a and caspase 7 and higher IL-10 and IL-6 expression in IL than No WR mice. A single exposure to intense aerobic treadmill exercise increased pro-(TNF-a) and anti-(IL-10) inflammatory cytokine and pro-apoptotic protein (caspase 3) expression in IL. The percent of early and late apoptotic and dead IL were higher after acute exercise. Although long-term voluntary wheel running did not protect against acute exercise-induced changes in IL cytokine expression or apoptosis there was an overall anti-inflammatory effect observed as a result of wheel running in healthy mice.Copyright © 2010 Elsevier Inc. All rights reserved.PMID 20510350 PubMed - in processPublication TypesPublication Types Research Support Non-U.S. GovtLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information Services Supplemental Content Related citations Voluntary exercise training in mice increases the expression of antioxidant enzymes and decreases the expression of TNF-alpha in intestinal lymphocytes. Brain Behav Immun. 2009 Voluntary exercise training in mice increases the expression of antioxidant enzymes and decreases the expression of TNF-alpha in intestinal lymphocytes.Hoffman-Goetz L Pervaiz N Guan J. Brain Behav Immun. 2009 May 23(4)498-506. Epub 2009 Feb 4. Dietary lactoferrin does not prevent dextran sulfate sodium induced murine intestinal lymphocyte death. Exp Biol Med (Maywood). 2008 Dietary lactoferrin does not prevent dextran sulfate sodium induced murine intestinal lymphocyte death.Spagnuolo PA Hoffman-Goetz L. 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Exerc Immunol Rev. 2010 16138-62. See reviews... See all... Recent activity Clear Turn Off Turn On Freewheel training decreases pro- and increases anti-inflammatory cytokine expre... Freewheel training decreases pro- and increases anti-inflammatory cytokine expression in mouse intestinal lymphocytes.Brain Behav Immun. 2010 Oct 24(7)1105-15. Epub 2010 May 25 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... 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