Abstract : In vitro physicochemical and antioxidant properties of mixture of Flax/Sesame (LS) and Flax/Peanut
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Abstract : In vitro physicochemical and antioxidant properties of mixture of Flax/Sesame (LS) and Flax/Peanut (LA) and in vivo hypolipidemic antioxidant and hepatoprotective activities were carried out to ascertain the claim of its utilisation against diseases. The seeds mixture rich in unsaturated fatty acids were prepared with 5/1 ratio of omega-6/omega-3 fatty acids and were orally administered ad libitum to rats by standard diet for 30 days. High cholesterol fed diet rats (CD-chol) exhibited a significant increase in total plasma and liver lipid parameters and atherogenicity and a significant decrease in high-density lipoproteins (HDL) and HDL/TC ratio (HTR). Administration of (LS) or (LA) seeds mixture to hypercholesterolemic rats (MS-LSchol and MS-LAchol groups respectively) significantly ameliorated lipid parameters and showed an increase of PUFAs (ALA and LA) and MUFAs and a decrease of SFAs in plasma and liver of MS-LSchol and MS-LAchol groups. Furthermore malondialdehyde levels decreased and the efficiency of antioxidant defense system was improved compared to CD-chol group. Liver histological sections showed lipid storage in hepatocytes of CD-chol group and an improvement was noted in both supplemented groups. Our results suggested that seeds mixtures of Flax/Sesame and Flax/Peanut have anti-atherogenic and hepatoprotective effects.Copyright (c) 2010 Elsevier Ltd. All rights reserved.PMID 20510326 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types Research Support Non-U.S. GovtMeSH TermsAnimalsAntioxidants/analysisAntioxidants/pharmacologyArachis hypogaea/chemistryChlorophyll/analysisDietDietary Carbohydrates/analysisDietary Fats/analysisDietary Proteins/analysisDrug-Induced Liver Injury/prevention amp control*Fatty Acids/analysisFatty Acids Omega-3/chemistry*Fatty Acids Omega-3/pharmacology*Fatty Acids Omega-6/chemistry*Fatty Acids Omega-6/pharmacology*Flax/chemistryHypercholesterolemia/bloodHypercholesterolemia/prevention amp controlHypolipidemic Agents/pharmacology*Liver/drug effectsLiver/metabolismMaleOxidants/bloodPhenols/analysisProtective Agents/pharmacology*RatsRats WistarSeeds/chemistry*Sesamum/chemistrySubstancesAntioxidantsDietary CarbohydratesDietary FatsDietary ProteinsFatty AcidsFatty Acids Omega-3Fatty Acids Omega-6Hypolipidemic AgentsOxidantsPhenolsProtective AgentsChlorophyllLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesMedicalDietary Fats - MedlinePlus Health Information Supplemental Content Related citations Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic rats. 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All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Hypolipidemic and hepatoprotective seeds mixture diet rich in omega-3 and omega-... Hypolipidemic and hepatoprotective seeds mixture diet rich in omega-3 and omega-6 fatty acids.Food Chem Toxicol. 2010 Aug-Sep 48(8-9)2239-46. Epub 2010 May 25 . PubMed Your browsing activity is empty. 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