Abstract : Topical tacrolimus and pimecrolimus are indicated for treatment of atopic dermatitis but they have
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Abstract : Topical tacrolimus and pimecrolimus are indicated for treatment of atopic dermatitis but they have been studied in many off-label uses. Double-blind and open studies have shown favorable results with topical tacrolimus and pimecrolimus in oral lichen planus. In 1 study of oral lichen planus blood tacrolimus was detected in 54 of patients but there were no signs of systemic toxicity. Double-blind and open studies of vitiligo have shown favorable results with tacrolimus in combination with excimer laser especially for lesions over bony prominences and on extremities. Similarly double-blind studies of vitiligo have shown favorable results when pimecrolimus is combined with narrow-band UVB especially for facial lesions. Double-blind and open studies of psoriasis have shown favorable results for tacrolimus and pimecrolimus especially for inverse psoriasis. Topical calcineurin inhibitors have been effective in many other cutaneous disorders and further studies would help clarify their roles.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20510763 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types ReviewMeSH TermsAdministration CutaneousCalcineurin/antagonists amp inhibitors*ChildChild PreschoolCrohn Disease/drug therapyDermatitis Atopic/drug therapyDermatologic Agents/therapeutic useDouble-Blind MethodFemaleHumansLichen Planus Oral/drug therapyLupus Erythematosus Cutaneous/drug therapyMaleOff-Label UsePsoriasis/drug therapyRosacea/drug therapySkin Diseases/drug therapy*Tacrolimus/analogs amp derivatives*Tacrolimus/therapeutic use*Therapies Investigational*Vitiligo/drug therapySubstancesDermatologic AgentspimecrolimusTacrolimusCalcineurinLinkOut - more resourcesFull Text SourcesElsevier ScienceW.B. SaundersMD ConsultMedicalSkin Conditions - MedlinePlus Health Information Supplemental Content Related citations Review Use of pimecrolimus cream in disorders other than atopic dermatitis. J Cutan Med Surg. 2008 Review Use of pimecrolimus cream in disorders other than atopic dermatitis.Day I Lin AN. J Cutan Med Surg. 2008 Jan-Feb 12(1)17-26. Review The role of topical calcineurin inhibitors for skin diseases other than atopic dermatitis. Am J Clin Dermatol. 2007 Review The role of topical calcineurin inhibitors for skin diseases other than atopic dermatitis.Wollina U. Am J Clin Dermatol. 2007 8(3)157-73. Review Potential new indications of topical calcineurin inhibitors. Dermatology. 2007 Review Potential new indications of topical calcineurin inhibitors.Luger T Paul C. Dermatology. 2007 215 Suppl 145-54. Epub 2007 Dec 18. Review Topical pimecrolimus for skin disease other than atopic dermatitis. Expert Opin Pharmacother. 2006 Review Topical pimecrolimus for skin disease other than atopic dermatitis.Wollina U Hansel G Koch A Abdel-Naser MB. Expert Opin Pharmacother. 2006 Oct 7(14)1967-75. Review Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis. Am J Clin Dermatol. 2005 Review Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis.Breuer K Werfel T Kapp A. Am J Clin Dermatol. 2005 6(2)65-77. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Innovative use of topical calcineurin inhibitors. Innovative use of topical calcineurin inhibitors.Dermatol Clin. 2010 Jul 28(3)535-45. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... 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