Abstract : Great insight has been gained into the structure and function of the inositol 145 trisphosphate rec
more
Abstract : Great insight has been gained into the structure and function of the inositol 145 trisphosphate receptor (InsP(3)R) by studies employing mutagenesis of the cDNA encoding the receptor. Notably early studies using this approach defined the key constituents required for InsP(3) binding in the N-terminus and the membrane spanning regions in the C-terminal domain responsible for channel formation targeting and function. In this article we evaluate recent studies which have used a similar approach to investigate key residues underlying the in vivo modulation by select regulatory factors. In addition we review studies defining the structural requirements in the channel domain which comprise the conduction pathway and are suggested to be involved in the gating of the channel.2010 Elsevier Ltd. All rights reserved.PMID 20510450 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types ReviewMeSH TermsCalcium Channels/metabolismCyclic AMP-Dependent Protein Kinases/metabolismCyclic GMP-Dependent Protein Kinases/metabolismInositol 145-Trisphosphate Receptors/chemistry*Inositol 145-Trisphosphate Receptors/geneticsInositol 145-Trisphosphate Receptors/metabolism*MutagenesisProtein Structure TertiarySubstancesCalcium ChannelsInositol 145-Trisphosphate ReceptorsCyclic AMP-Dependent Protein KinasesCyclic GMP-Dependent Protein KinasesLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesOther Literature SourcesCOS Scholar Universe Supplemental Content Related citations Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 145-trisphosphate receptor. J Biol Chem. 2004 Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 145-trisphosphate receptor.Wagner LE 2nd Li WH Joseph SK Yule DI. J Biol Chem. 2004 Oct 29 279(44)46242-52. Epub 2004 Aug 11. The contribution of serine residues 1588 and 1755 to phosphorylation of the type I inositol 145-trisphosphate receptor by PKA and PKG. FEBS Lett. 2004 The contribution of serine residues 1588 and 1755 to phosphorylation of the type I inositol 145-trisphosphate receptor by PKA and PKG.Soulsby MD Alzayady K Xu Q Wojcikiewicz RJ. FEBS Lett. 2004 Jan 16 557(1-3)181-4. Regulation of single inositol 145-trisphosphate receptor channel activity by protein kinase A phosphorylation. J Physiol. 2008 Regulation of single inositol 145-trisphosphate receptor channel activity by protein kinase A phosphorylation.Wagner LE 2nd Joseph SK Yule DI. J Physiol. 2008 Aug 1 586(Pt 15)3577-96. Epub 2008 Jun 5. Review Regulation of inositol 145-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. Biochim Biophys Acta. 2009 Review Regulation of inositol 145-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.Vanderheyden V Devogelaere B Missiaen L De Smedt H Bultynck G Parys JB. Biochim Biophys Acta. 2009 Jun 1793(6)959-70. Epub 2008 Dec 16. Review The complex regulatory function of the ligand-binding domain of the inositol 145-trisphosphate receptor. Cell Calcium. 2008 Review The complex regulatory function of the ligand-binding domain of the inositol 145-trisphosphate receptor.Devogelaere B Verbert L Parys JB Missiaen L De Smedt H. Cell Calcium. 2008 Jan 43(1)17-27. Epub 2007 May 17. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Linking structure to function Recent lessons from inositol 145-trisphosphate ... Linking structure to function Recent lessons from inositol 145-trisphosphate receptor mutagenesis.Cell Calcium. 2010 Jun 47(6)469-79. Epub 2010 May 26 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
less