Abstract : Impairment of varicella zoster virus (VZV)-specific cell-mediated immunity including impairment due
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Abstract : Impairment of varicella zoster virus (VZV)-specific cell-mediated immunity including impairment due to immunosenescence is associated with an increased risk of developing herpes zoster (HZ) whereas levels of anti-VZV antibodies do not correlate with HZ risk. This crucial role of VZV-specific cell-mediated immunity suggests that boosting these responses by vaccination will be an effective strategy for reducing the burden of HZ. Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants anticonvulsants and analgesics.2010 Elsevier B.V. All rights reserved.PMID 20510262 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types Research Support N.I.H. ExtramuralResearch Support Non-U.S. GovtResearch Support U.S. Govt Non-P.H.S.ReviewMeSH TermsAdultAgedAnalgesics/therapeutic useAnticonvulsants/therapeutic useAntidepressive Agents Tricyclic/therapeutic useAntiviral Agents/therapeutic use*Herpes Zoster/complicationsHerpes Zoster/immunologyHerpes Zoster/prevention amp control*Herpes Zoster Vaccine/administration amp dosage*Herpes Zoster Vaccine/immunologyHerpesvirus 3 Human/immunology*HumansImmunity Cellular/immunologyIncidenceMiddle AgedNeuralgia Postherpetic/drug therapyNeuralgia Postherpetic/immunologyNeuralgia Postherpetic/prevention amp control*Randomized Controlled Trials as TopicTreatment OutcomeVaccinationSubstancesAnalgesicsAnticonvulsantsAntidepressive Agents TricyclicAntiviral AgentsHerpes Zoster VaccineLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesOther Literature SourcesCOS Scholar UniverseEducationNew England Research Institutes Inc.MedicalShingles - MedlinePlus Health Information Supplemental Content Related citations Review Zoster vaccine (Zostavax) a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults. Drugs Aging. 2010 Review Zoster vaccine (Zostavax) a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults.Sanford M Keating GM. Drugs Aging. 2010 Feb 1 27(2)159-76. Review Management of herpes zoster and post-herpetic neuralgia now and in the future. J Clin Virol. 2010 Review Management of herpes zoster and post-herpetic neuralgia now and in the future.Whitley RJ Volpi A McKendrick M Wijck A Oaklander AL. J Clin Virol. 2010 May 48 Suppl 1S20-8. Vaccination against Herpes Zoster and Postherpetic Neuralgia. J Infect Dis. 2008 Vaccination against Herpes Zoster and Postherpetic Neuralgia.Oxman MN Levin MJ Shingles Prevention Study Group. J Infect Dis. 2008 Mar 1 197 Suppl 2S228-36. Review Vaccination to prevent herpes zoster and postherpetic neuralgia. Hum Vaccin. 2007 Review Vaccination to prevent herpes zoster and postherpetic neuralgia.Oxman MN. Hum Vaccin. 2007 Mar-Apr 3(2)64-8. Epub 2007 Mar 23. Review How I prevent...herpes zoster by vaccination. Rev Med Liege. 2007 Review How I prevent...herpes zoster by vaccination.Nikkels AF Piérard GE. Rev Med Liege. 2007 Jan 62(1)44-7. See reviews... See all... Cited by 1 PubMed Central article Predictors of pain intensity and persistence in a prospective Italian cohort of patients with herpes zoster relevance of smoking trauma and antiviral therapy. BMC Med. 2010 Predictors of pain intensity and persistence in a prospective Italian cohort of patients with herpes zoster relevance of smoking trauma and antiviral therapy.Parruti G Tontodonati M Rebuzzi C Polilli E Sozio F Consorte A Agostinone A Di Masi F Congedo G DAntonio D et al. BMC Med. 2010 Oct 11 858. Epub 2010 Oct 11. All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Cited in PMC Full-text articles in the PubMed Central Database that cite the current articles. Recent activity Clear Turn Off Turn On Prevention strategies for herpes zoster and post-herpetic neuralgia. Prevention strategies for herpes zoster and post-herpetic neuralgia.J Clin Virol. 2010 May 48 Suppl 1S14-9. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... 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