Abstract : Nuclear retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs are pote
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Abstract : Nuclear retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs are potential candidates as drug target for cancer prevention and treatment. We investigated if the rexinoid 6-OH-11-O-hydroxyphenantrene (IIF) potentiates the antitumoral properties of PPARgamma ligands as ciglitazone and pioglitazone on two colon cancer cell lines HCA-7 and HCT-116. Drugs inhibited cell growth and induced apoptosis synergistically. The combination resulted in a decrease of cyclooxigenase-2 metalloproteinases-2 and -9 expression level and activity while PPARgamma RXRgamma and tissue inhibitors of metalloproteinase-1 and -2 expression were increased. Finally IIF potentiated PPAR transcriptional activity by enhancement of peroxisome proliferator response elements transactivation.2010 Elsevier Ireland Ltd. All rights reserved.PMID 20510503 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types Research Support Non-U.S. GovtMeSH TermsAntineoplastic Combined Chemotherapy Protocols/pharmacology*Apoptosis/drug effectsCell Movement/drug effects*Cell Proliferation/drug effects*Cell Survival/drug effectsColonic Neoplasms/geneticsColonic Neoplasms/metabolismColonic Neoplasms/pathology*Cyclooxygenase 2/metabolismDose-Response Relationship DrugDrug SynergismHCT116 CellsHumansLigandsMatrix Metalloproteinase 2/metabolismMatrix Metalloproteinase 9/metabolismNeoplasm InvasivenessPPAR gamma/agonists*PPAR gamma/geneticsPPAR gamma/metabolismResponse Elements/drug effectsRetinoid X Receptor gamma/agonists*Retinoid X Receptor gamma/metabolismThiazolidinediones/pharmacologyTissue Inhibitor of Metalloproteinase-1/metabolismTissue Inhibitor of Metalloproteinase-2/metabolismTranscriptional Activation/drug effectsTretinoin/analogs amp derivativesTretinoin/pharmacologySubstancesIIF compoundLigandsPPAR gammaRetinoid X Receptor gammaThiazolidinedionesTissue Inhibitor of Metalloproteinase-1pioglitazoneTissue Inhibitor of Metalloproteinase-2TretinoinciglitazoneCyclooxygenase 2PTGS2 protein humanMMP2 protein humanMatrix Metalloproteinase 2Matrix Metalloproteinase 9LinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesMolecular Biology DatabasesTRANS-RETINOIC ACID - HSDB Supplemental Content Related citations Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells. Oncol Rep. 2009 Enhanced effects of PPARgamma ligands and RXR selective retinoids in combination to inhibit migration and invasiveness in cancer cells.Papi A Rocchi P Ferreri AM Guerra F Orlandi M. Oncol Rep. 2009 Apr 21(4)1083-9. PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. J Neurochem. 2009 PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.Papi A Tatenhorst L Terwel D Hermes M Kummer MP Orlandi M Heneka MT. J Neurochem. 2009 Jun 109(6)1779-90. Epub 2009 May 11. Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management. Gut. 2007 Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management.Yamazaki K Shimizu M Okuno M Matsushima-Nishiwaki R Kanemura N Araki H Tsurumi H Kojima S Weinstein IB Moriwaki H. Gut. 2007 Nov 56(11)1557-63. Epub 2007 Jun 29. Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment. Mol Cancer Ther. 2004 Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment.Klopper JP Hays WR Sharma V Baumbusch MA Hershman JM Haugen BR. Mol Cancer Ther. 2004 Aug 3(8)1011-20. Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells. Int J Gastrointest Cancer. 2002 Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells.Hashimoto K Ethridge RT Evers BM. Int J Gastrointest Cancer. 2002 32(1)7-22. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Gene Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources. Gene (GeneRIF) Gene records that have the current articles as Reference into Function citations (GeneRIFs). 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