Abstract : Concurrent EEG-fMRI studies have provided increasing details of the dynamics of intrinsic brain act
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Abstract : Concurrent EEG-fMRI studies have provided increasing details of the dynamics of intrinsic brain activity during the resting state. Here we investigate a prominent effect in EEG during relaxed resting i.e. the increase of the alpha power when the eyes are closed compared to when the eyes are open. This phenomenon is related to changes in thalamo-cortical and cortico-cortical synchronization. In order to investigate possible changes to EEG-fMRI coupling and fMRI functional connectivity during the two states we adopted a data-driven approach that fuses the multimodal data on the basis of parallel ICA decompositions of the fMRI data in the spatial domain and of the EEG data in the spectral domain. The power variation of a posterior alpha component was used as a reference function to deconvolve the hemodynamic responses from occipital frontal temporal and subcortical fMRI components. Additionally we computed the functional connectivity between these components. The results showed widespread alpha hemodynamic responses and high functional connectivity during eyes-closed (EC) rest while eyes open (EO) resting abolished many of the hemodynamic responses and markedly decreased functional connectivity. These data suggest that generation of local hemodynamic responses is highly sensitive to state changes that do not involve changes of mental effort or awareness. They also indicate the localized power differences in posterior alpha between EO and EC in resting state data are accompanied by spatially widespread amplitude changes in hemodynamic responses and inter-regional functional connectivity i.e. low frequency hemodynamic signals display an equivalent of alpha reactivity.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20510374 PubMed - indexed for MEDLINEPublication Types MeSH Terms Grant SupportPublication Types Research Support N.I.H. ExtramuralResearch Support Non-U.S. GovtMeSH TermsAdultBiological Clocks/physiology*Brain/physiology*Brain Mapping/methods*Cerebrovascular Circulation/physiologyElectroencephalography/methods*FemaleHumansMagnetic Resonance Imaging/methods*MaleNerve Net/physiology*Neural Pathways/physiologyRest/physiology*Subtraction TechniqueGrant Support1 R01 EB 000840/EB/NIBIB NIH HHS/United States1 R01 EB 005846/EB/NIBIB NIH HHS/United StatesR01 EB000840-01/EB/NIBIB NIH HHS/United StatesR01 EB000840-02/EB/NIBIB NIH HHS/United StatesR01 EB000840-03/EB/NIBIB NIH HHS/United StatesR01 EB000840-04/EB/NIBIB NIH HHS/United StatesR01 EB000840-05/EB/NIBIB NIH HHS/United StatesR01 EB000840-06/EB/NIBIB NIH HHS/United StatesR01 EB000840-07/EB/NIBIB NIH HHS/United StatesR01 EB000840-08/EB/NIBIB NIH HHS/United StatesR01 EB000840-09/EB/NIBIB NIH HHS/United StatesR01 EB005846-01/EB/NIBIB NIH HHS/United StatesR01 EB005846-02/EB/NIBIB NIH HHS/United StatesR01 EB005846-03/EB/NIBIB NIH HHS/United StatesR01 EB005846-04/EB/NIBIB NIH HHS/United StatesR01 EB005846-05A1/EB/NIBIB NIH HHS/United StatesR01 EB005846-06/EB/NIBIB NIH HHS/United StatesR01 EB005846-07/EB/NIBIB NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOSwets Information ServicesMedicalMRI Scans - MedlinePlus Health Information Supplemental Content Related citations EEG-fMRI reciprocal functional neuroimaging. 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Review Human brain mapping hemodynamic response and electrophysiology. Clin Neurophysiol. 2008 Review Human brain mapping hemodynamic response and electrophysiology.Shibasaki H. Clin Neurophysiol. 2008 Apr 119(4)731-43. Epub 2008 Jan 9. See reviews... See all... Recent activity Clear Turn Off Turn On Reactivity of hemodynamic responses and functional connectivity to different sta... Reactivity of hemodynamic responses and functional connectivity to different states of alpha synchrony a concurrent EEG-fMRI study.Neuroimage. 2010 Oct 1 52(4)1252-60. Epub 2010 May 25 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... 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