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Reference : Mediators Inflamm.~EBSCO~http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&sid=Pu    more

Reference : Mediators Inflamm.~EBSCO~http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&sid=PubMed&issn=0962-9351&title=Mediators%20Inflamm&volume=2010&issue=&spage=513948&atitle=Release%20of%20inflammatory%20mediators%20by%20human%20adipose%20tissue%    less

Abstract : This paper considers the role of putative adipokines that might be involved in the enhanced inflamm    more

Abstract : This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity. Inflammatory adipokines IL-6 IL-10 ACE TGFbeta1 TNFalpha IL-1beta PAI-1 and IL-8 plus one anti-inflammatory IL-10 adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue. In contrast the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue. The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed. The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.    less