Abstract : Abstract Considering the currently increased incidence, prevalence and survival of prostate cancer    more

Abstract : Abstract Considering the currently increased incidence, prevalence and survival of prostate cancer, the management of hot flashes associated with LH-RH analog treatment must be taken into account. The most widely used and effective treatment is hormone replacement, though the latter is not without risks. It is presently possible to address hot flushes in these patients based on a broad range of treatment options in which hormone therapy may constitute a last option, due to the risk of tumour relapse or progression – since prostate cancer is hormone sensitive. The present study reviews the currently used treatments and hygiene-dietary measures that may help reduce the symptoms. A review is made of both hormonal and nonhormonal therapies, based on the existing scientific evidence. Drugs such as the new antidepressants, gabapentin and clonidine may play an important role in the management of hot flashes. While the underlying mechanisms of action are varied, they are related to the complex feedback exerted by the sexual hormones upon the hypothalamic secretion of noradrenaline – this being the principal etiological factor of hot flashes. Keywords: Prostate carcinoma, hot flashes/flushes, hormone deprivation, treatment, antidepressants, clonidine, gabapentin, hormone replacement therapy.- Slides    less