Abstract : During T cell development in the thymus a virgin repertoire of diverse TCRalphabeta recognition spe
more
Abstract : During T cell development in the thymus a virgin repertoire of diverse TCRalphabeta recognition specificities in immature thymocytes is selected through positive and negative selection to form an immunocompetent and self-tolerant repertoire of mature T cells. Positive selection supports the survival of thymocytes that receive weak signals of low-avidity TCR engagement whereas negative selection deletes potentially harmful self-reactive thymocytes upon high-avidity TCR engagement. Early studies have highlighted the role of TCR interaction with polymorphic MHC determinants in positive selection while negative selection imposes TCR specificity to peptide antigens displayed by MHC molecules. However recent advances in the biology of thymic stromal cells have indicated that the formation of an immunocompetent TCR repertoire requires positive selection by thymic cortical epithelial cells expressing a unique protein degradation machinery suggesting the role of self-peptide repertoire specifically expressed by thymic cortical epithelial cells in the development of the acquired immune system.Copyright 2010 Elsevier Ltd. All rights reserved.PMID 20510627 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types Research Support Non-U.S. GovtReviewMeSH TermsAnimalsHistocompatibility Antigens/geneticsHistocompatibility Antigens/immunology*HumansPeptides/immunology*Receptors Antigen T-Cell/immunology*T-Lymphocytes/immunology*Thymus Gland/immunology*SubstancesHistocompatibility AntigensPeptidesReceptors Antigen T-CellLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information Services Supplemental Content Related citations Review Thymic microenvironments for T-cell repertoire formation. Adv Immunol. 2008 Review Thymic microenvironments for T-cell repertoire formation.Nitta T Murata S Ueno T Tanaka K Takahama Y. Adv Immunol. 2008 9959-94. A unified model for T cell antigen recognition and thymic selection of the T cell repertoire. J Theor Biol. 1991 A unified model for T cell antigen recognition and thymic selection of the T cell repertoire.Mannie MD. J Theor Biol. 1991 Jul 21 151(2)169-92. Review Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection. Curr Top Microbiol Immunol. 2005 Review Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.Coutinho A Caramalho I Seixas E Demengeot J. Curr Top Microbiol Immunol. 2005 29343-71. Thymic selection process induced by hybrid antibodies. Nature. 1988 Thymic selection process induced by hybrid antibodies.Zepp F Staerz UD. Nature. 1988 Dec 1 336(6198)473-5. A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection. J Immunol. 2001 A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection.Viret C SantAngelo DB He X Ramaswamy H Janeway CA Jr. J Immunol. 2001 Apr 1 166(7)4429-37. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Role of thymic cortex-specific self-peptides in positive selection of T cells. Role of thymic cortex-specific self-peptides in positive selection of T cells.Semin Immunol. 2010 Oct 22(5)287-93. Epub 2010 May 26 . PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
less