Abstract : The human immune defense system is composed of two distinct elements innate immunity located primar
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Abstract : The human immune defense system is composed of two distinct elements innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases however such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines.Copyright (c) 2009 Elsevier Ltd. All rights reserved.PMID 20510740 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types ReviewMeSH TermsAIDS Vaccines/immunology*Antigen Presentation/immunologyAntigens CD1/immunology*Dendritic Cells/immunologyHIV Infections/immunology*HumansImmunity Innate*Major Histocompatibility ComplexSpecies SpecificitySubstancesAIDS VaccinesAntigens CD1LinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesMedicalHIV/AIDS - MedlinePlus Health Information Supplemental Content Related citations Review CD1 antigen presentation and infectious disease. Contrib Microbiol. 2003 Review CD1 antigen presentation and infectious disease.Dascher CC Brenner MB. Contrib Microbiol. 2003 10164-82. Review CD1 proteins targets of T cell recognition in innate and adaptive immunity. Rev Immunogenet. 2000 Review CD1 proteins targets of T cell recognition in innate and adaptive immunity.Ulrichs T Porcelli SA. Rev Immunogenet. 2000 2(3)416-32. Review CD1-restricted T cells in host defense to infectious diseases. Curr Top Microbiol Immunol. 2007 Review CD1-restricted T cells in host defense to infectious diseases.Behar SM Porcelli SA. Curr Top Microbiol Immunol. 2007 314215-50. Review Dendritic cells as a conduit to improve HIV vaccines. Curr Mol Med. 2003 Review Dendritic cells as a conduit to improve HIV vaccines.Pope M. Curr Mol Med. 2003 May 3(3)229-42. Innate immune system damage in human immunodeficiency virus type 1 infection. Implications for acquired immunity and vaccine design. Am J Respir Crit Care Med. 2000 Innate immune system damage in human immunodeficiency virus type 1 infection. Implications for acquired immunity and vaccine design.Howie S Ramage R Hewson T. Am J Respir Crit Care Med. 2000 Oct 162(4 Pt 2)S141-5. See reviews... See all... Recent activity Clear Turn Off Turn On Species-specific CD1-restricted innate immunity for the development of HIV vacci... Species-specific CD1-restricted innate immunity for the development of HIV vaccine.Vaccine. 2010 May 26 28 Suppl 2B3-7. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here NCBI gt Literature gt PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training amp Tutorials Resources Chemicals amp BioassaysData amp SoftwareDNA amp RNADomains amp StructuresGenes amp ExpressionGenetics amp MedicineGenomes amp MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyTraining amp TutorialsVariation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information U.S. National Library of Medicine 8600 Rockville Pike Bethesda MD 20894 USA
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