Abstract : Hippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing
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Abstract : Hippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing under social and physical deprivation in gerbils (Meriones unguiculatus). We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus musculus). We examined synaptic turnover rates in the dentate gyrus CA3 CA1 subiculum and entorhinal cortex. No direct effects of deprived rearing on rates of synaptic turnover were found in any of the studied regions. However adult wheel running had the effect of leveling layer-specific differences in synaptic remodeling in the dentate gyrus CA3 and CA1 but not in the entorhinal cortex and subiculum of animals of both rearing treatments. Epigenetic effects during juvenile development affected adult neural plasticity in mice but seemed to be less pronounced than in gerbils.
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