Abstract : The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on dif
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Abstract : The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H(2)O(2)-induced cell death associated with a marked reduction in caspase-3 activation was observed. Moreover activation of NF-kappaB a known regulator of a host of genes that involves in specific stress and inflammatory responses by H(2)O(2) was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases.Copyright 2010 Elsevier Ltd. All rights reserved.PMID 20510620 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types Research Support Non-U.S. GovtMeSH TermsAnimalsCaspase 3/metabolismHydrogen Peroxide/pharmacologyNF-kappa B/antagonists amp inhibitorsNF-kappa B/metabolismNeuroprotective Agents/chemical synthesis*Neuroprotective Agents/chemistryNeuroprotective Agents/pharmacologyOxidative Stress/drug effectsPC12 CellsRatsReactive Oxygen Species/metabolismTriazines/chemical synthesisTriazines/chemistry*Triazines/pharmacologySubstancesNF-kappa BNeuroprotective AgentsReactive Oxygen SpeciesTriazines124-triazineHydrogen PeroxideCaspase 3LinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOOhioLINK Electronic Journal CenterSwets Information ServicesOther Literature SourcesCOS Scholar UniverseMolecular Biology DatabasesHYDROGEN PEROXIDE - HSDB Supplemental Content Related citations Attenuation of NF-kappaB and activation of Nrf2 signaling by 124-triazine derivatives protects neuron-like PC12 cells against apoptosis. Apoptosis. 2010 Attenuation of NF-kappaB and activation of Nrf2 signaling by 124-triazine derivatives protects neuron-like PC12 cells against apoptosis.Tusi SK Ansari N Amini M Amirabad AD Shafiee A Khodagholi F. Apoptosis. 2010 Jun 15(6)738-51. Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals. Mutat Res. 2009 Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals.Cho ES Jang YJ Hwang MK Kang NJ Lee KW Lee HJ. Mutat Res. 2009 Feb 10 661(1-2)18-24. Epub 2008 Nov 5. Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-kappaB activation. J Biol Chem. 2004 Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-kappaB activation.Jang JH Surh YJ. J Biol Chem. 2004 Sep 10 279(37)38779-86. Epub 2004 Jun 18. Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells. J Food Sci. 2009 Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells.Chan KC Mong MC Yin MC. J Food Sci. 2009 Sep 74(7)H225-31. Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells involvement of nuclear factor kappa B Bax and Bcl-2. J Pineal Res. 2006 Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells involvement of nuclear factor kappa B Bax and Bcl-2.Chetsawang B Putthaprasart C Phansuwan-Pujito P Govitrapong P. J Pineal Res. 2006 Sep 41(2)116-23. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. BioAssay PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Synthesis and in vitro evaluation of novel 124-triazine derivatives as neuropr... Synthesis and in vitro evaluation of novel 124-triazine derivatives as neuroprotective agents.Bioorg Med Chem. 2010 Jun 15 18(12)4224-30. Epub 2010 May 8 . PubMed Your browsing activity is empty. 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