Abstract : The zinc finger transcription factor ZNF24 is a relatively uncharacterized Krüppel-like transcripti
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Abstract : The zinc finger transcription factor ZNF24 is a relatively uncharacterized Krüppel-like transcription factor displaying a suppressive effect on the transcription. ZNF24 is involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF transcription. In a previous study our analysis reveals that ZNF24 is a pleiotropic factor that has a role in hematopoiesis brain development and cancers. Activation of PDGFR-beta is critically involved into various cell functions including recruitment of stromal cells and VEGF induction in tumor and perivascular cells. Here overexpression of ZNF24 resulted in a significant down-regulation of PDGFR-beta whereas silencing of ZNF24 with small interfering RNA led to increased PDGFR-beta expression. Overexpression of ZNF24 resulted in a significant decrease in PDGFR-beta promoter activity. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription.Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.PMID 20510677 PubMed - indexed for MEDLINEPublication Types MeSH Terms SubstancesPublication Types Research Support Non-U.S. GovtMeSH TermsCell LineCell Line TumorDown-RegulationGene Expression Regulation*Gene Knockdown TechniquesHumansKruppel-Like Transcription Factors/geneticsKruppel-Like Transcription Factors/metabolism*Promoter Regions GeneticRNA Small Interfering/geneticsReceptor Platelet-Derived Growth Factor beta/genetics*Repressor Proteins/geneticsRepressor Proteins/metabolism*Transcription GeneticUp-RegulationZinc Fingers*SubstancesKruppel-Like Transcription FactorsRNA Small InterferingRepressor ProteinsZNF24 protein humanReceptor Platelet-Derived Growth Factor betaLinkOut - more resourcesFull Text SourcesElsevier ScienceEBSCOSwets Information ServicesMedicalVascular Brain Tumor - Genetic Alliance Supplemental Content Related citations Repression of vascular endothelial growth factor expression by the zinc finger transcription factor ZNF24. Cancer Res. 2007 Repression of vascular endothelial growth factor expression by the zinc finger transcription factor ZNF24.Harper J Yan L Loureiro RM Wu I Fang J DAmore PA Moses MA. Cancer Res. 2007 Sep 15 67(18)8736-41. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep a novel wt-1/egr-related zinc finger repressor. Mol Cell Biol. 1999 Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep a novel wt-1/egr-related zinc finger repressor.Imhof A Schuierer M Werner O Moser M Roth C Bauer R Buettner R. Mol Cell Biol. 1999 Jan 19(1)194-204. Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression. Oncogene. 2007 Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.Shiraishi K Yamasaki K Nanba D Inoue H Hanakawa Y Shirakata Y Hashimoto K Higashiyama S. Oncogene. 2007 Jan 18 26(3)339-48. Epub 2006 Jul 24. The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. J Biol Chem. 2004 The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter.Noti JD Johnson AK Dillon JD. J Biol Chem. 2004 Jun 25 279(26)26948-58. Epub 2004 Apr 15. Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. Oncogene. 2009 Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.Zheng HQ Zhou Z Huang J Chaudhury L Dong JT Chen C. Oncogene. 2009 Oct 22 28(42)3702-13. Epub 2009 Aug 10. See reviews... See all... 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