Abstract : The actions of the vitamin D hormone 125-dihydroxyvitamin D(3) (125(OH)(2)D(3)) are mediated by the
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Abstract : The actions of the vitamin D hormone 125-dihydroxyvitamin D(3) (125(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR) a ligand-activated transcription factor that functions to control gene expression. After ligand activation the VDR binds directly to specific sequences located near promoters and recruits a variety of coregulatory complexes that perform the additional functions required to modify transcriptional output. Recent advances in transcriptional regulation which permit the unbiased identification of the regulatory regions of genes are providing new insight into how genes are regulated. Surprisingly gene regulation requires the orchestrated efforts of multiple modular enhancers often located many kilobases upstream downstream or within the transcription units themselves. These studies are transforming our understanding of how 125(OH)(2)D(3) regulates gene transcription.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20511050 PubMed - indexed for MEDLINEPMCID PMC2879406 Available on 2011/6/1Publication Types MeSH Terms Substances Grant SupportPublication Types Research Support N.I.H. ExtramuralReviewMeSH TermsAnimalsCalcitriol/geneticsCalcitriol/metabolism*Enhancer Elements GeneticGene Expression Regulation*Histones/metabolismHomeostasis/geneticsHumansMiceMinerals/metabolismRANK Ligand/metabolismRatsReceptors Calcitriol/geneticsReceptors Calcitriol/metabolism*Transcription GeneticSubstancesHistonesMineralsRANK LigandReceptors CalcitriolTnfsf11 protein mouseCalcitriolGrant SupportAR-045173/AR/NIAMS NIH HHS/United StatesDK-072281/DK/NIDDK NIH HHS/United StatesDK-073995/DK/NIDDK NIH HHS/United StatesDK-074993/DK/NIDDK NIH HHS/United StatesR01 AR045173-05/AR/NIAMS NIH HHS/United StatesR01 DK072281-04/DK/NIDDK NIH HHS/United StatesR01 DK072281-05/DK/NIDDK NIH HHS/United StatesR01 DK073995-02/DK/NIDDK NIH HHS/United StatesR01 DK074993-03/DK/NIDDK NIH HHS/United StatesR01 DK074993-04/DK/NIDDK NIH HHS/United StatesR01 DK074993-05/DK/NIDDK NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceW.B. SaundersMD ConsultOther Literature SourcesCOS Scholar UniverseMolecular Biology Databases125-DIHYDROXYCHOLECALCIFEROL - HSDB Supplemental Content Related citations Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 125-dihydroxyvitamin D3. Mol Endocrinol. 2006 Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 125-dihydroxyvitamin D3.Zella LA Kim S Shevde NK Pike JW. Mol Endocrinol. 2006 Jun 20(6)1231-47. Epub 2006 Feb 23. Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription. Mol Endocrinol. 2010 Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.Zella LA Meyer MB Nerenz RD Lee SM Martowicz ML Pike JW. Mol Endocrinol. 2010 Jan 24(1)128-47. Epub 2009 Nov 6. Perspectives on mechanisms of gene regulation by 125-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol. 2007 Perspectives on mechanisms of gene regulation by 125-dihydroxyvitamin D3 and its receptor.Pike JW Meyer MB Watanuki M Kim S Zella LA Fretz JA Yamazaki M Shevde NK. J Steroid Biochem Mol Biol. 2007 Mar 103(3-5)389-95. Epub 2007 Jan 12. Review The vitamin D hormone and its nuclear receptor molecular actions and disease states. J Endocrinol. 1997 Review The vitamin D hormone and its nuclear receptor molecular actions and disease states.Haussler MR Haussler CA Jurutka PW Thompson PD Hsieh JC Remus LS Selznick SH Whitfield GK. J Endocrinol. 1997 Sep 154 SupplS57-73. Review New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone. 1995 Review New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone.Haussler MR Jurutka PW Hsieh JC Thompson PD Selznick SH Haussler CA Whitfield GK. Bone. 1995 Aug 17(2 Suppl)33S-38S. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On The vitamin D receptor new paradigms for the regulation of gene expression by 1... The vitamin D receptor new paradigms for the regulation of gene expression by 125-dihydroxyvitamin D(3).Endocrinol Metab Clin North Am. 2010 Jun 39(2)255-69 table of contents. PubMed Your browsing activity is empty. 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