Abstract : Interaction with the immune system is one of the most well-established nonclassic effects of vitami
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Abstract : Interaction with the immune system is one of the most well-established nonclassic effects of vitamin D. For many years this was considered to be a manifestation of granulomatous diseases such sarcoidosis in which synthesis of active 125-dihydroxyvitamin D(3) (125(OH)(2)D(3)) is known to be dysregulated. However recent reports have supported a role for 125(OH)(2)D(3) in mediating normal function of the innate and adaptive immune systems. Crucially these effects seem to be mediated via localized autocrine or paracrine synthesis of 125(OH)(2)D(3) from precursor 25-hydroxyvitamin D(3) the main circulating metabolite of vitamin D. The ability of vitamin D to influence normal human immunity is highly dependent on the vitamin D status of individuals and may lead to aberrant response to infection or autoimmunity in those who are lacking vitamin D. The potential health significance of this has been underlined by increasing awareness of impaired vitamin D status in populations across the globe. This article describes some of the recent developments with respect to vitamin D and the immune system and possible clinical implications.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20511058 PubMed - indexed for MEDLINEPMCID PMC2879394 Available on 2011/6/1Publication Types MeSH Terms Substances Grant SupportPublication Types Research Support N.I.H. ExtramuralReviewMeSH Terms25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics25-Hydroxyvitamin D3 1-alpha-Hydroxylase/immunologyAdaptive Immunity*AnimalsAntigen Presentation/immunologyAntimicrobial Cationic Peptides/immunologyAutoimmune Diseases/immunology*B-Lymphocytes/immunologyCrohn Disease/immunologyDendritic Cells/immunologyDiabetes Mellitus Type 1/immunologyHumansImmune System*Immunity Innate*Macrophages/immunologyMiceMultiple Sclerosis/immunologyT-Lymphocytes/immunologyTuberculosis/immunologyVitamin D/immunology*Vitamin D/metabolismVitamin D/therapeutic useSubstancesAntimicrobial Cationic PeptidesVitamin DCAP18 lipopolysaccharide-binding protein25-Hydroxyvitamin D3 1-alpha-HydroxylaseGrant SupportR01AR050626/AR/NIAMS NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceW.B. SaundersMD ConsultMedicalVitamin D - MedlinePlus Health InformationImmune System and Disorders - MedlinePlus Health InformationAutoimmune Diseases - MedlinePlus Health Information Supplemental Content Related citations Review Vitamin D modulator of the immune system. Curr Opin Pharmacol. 2010 Review Vitamin D modulator of the immune system.Baeke F Takiishi T Korf H Gysemans C Mathieu C. Curr Opin Pharmacol. 2010 Aug 10(4)482-96. Epub 2010 Apr 27. Review Vitamin D and the intracrinology of innate immunity. Mol Cell Endocrinol. 2010 Review Vitamin D and the intracrinology of innate immunity.Hewison M. Mol Cell Endocrinol. 2010 Jun 10 321(2)103-11. Epub 2010 Feb 13. Review Vitamin D and molecular actions on the immune system modulation of innate and autoimmunity. J Mol Med. 2010 Review Vitamin D and molecular actions on the immune system modulation of innate and autoimmunity.Kamen DL Tangpricha V. J Mol Med. 2010 May 88(5)441-50. Epub 2010 Feb 1. 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Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Vitamin D and the immune system new perspectives on an old theme. Vitamin D and the immune system new perspectives on an old theme.Endocrinol Metab Clin North Am. 2010 Jun 39(2)365-79 table of contents. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... 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