Abstract : The biologically active metabolite of vitamin D 125(OH)(2)D(3) affects mineral homeostasis and has
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Abstract : The biologically active metabolite of vitamin D 125(OH)(2)D(3) affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 125(OH)(2)D(3). The role of extrarenal 1alpha(OH)ase in placenta and macrophages is also discussed as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases including bone loss disorders and certain immune diseases.Copyright 2010 Elsevier Inc. All rights reserved.PMID 20511049 PubMed - indexed for MEDLINEPMCID PMC2879391 Available on 2011/6/1Publication Types MeSH Terms Substances Grant SupportPublication Types Research Support N.I.H. ExtramuralReviewMeSH TermsAnimalsCholecalciferol/biosynthesis*Cholecalciferol/metabolism*Chronic DiseaseCytochrome P-450 CYP27A1/biosynthesis*FemaleHumansKidney/enzymologyKidney Diseases/metabolismLiver/enzymologyMacrophages/metabolismMicePlacenta/metabolismPregnancy/metabolismSteroid Hydroxylases/biosynthesis*Vitamin D/metabolism*Vitamin D Deficiency/metabolism*Vitamin D-Binding Protein/metabolism*SubstancesVitamin D-Binding ProteinVitamin DCholecalciferolCytochrome P-450 CYP27A1Steroid HydroxylasesCYP2R1 protein humanGrant SupportDK-38961-21/DK/NIDDK NIH HHS/United StatesLinkOut - more resourcesFull Text SourcesElsevier ScienceW.B. SaundersMD ConsultOther Literature SourcesCOS Scholar UniverseMedicalCancer Kidney - Genetic AllianceVitamin D - MedlinePlus Health InformationMalnutrition - MedlinePlus Health InformationMolecular Biology DatabasesCHOLECALCIFEROL - HSDB Supplemental Content Related citations Review Vitamin D metabolism regulation and associated diseases. Med Sci (Paris). 2006 Review Vitamin D metabolism regulation and associated diseases.Tissandié E Guéguen Y Lobaccaro JM Aigueperse J Souidi M. Med Sci (Paris). 2006 Dec 22(12)1095-100. Review Recent advances in our understanding of the vitamin D endocrine system. J Lab Clin Med. 1976 Review Recent advances in our understanding of the vitamin D endocrine system.De Luca HF. J Lab Clin Med. 1976 Jan 87(1)7-26. Review Vitamin D metabolism and chronic liver disease. Ann Clin Lab Sci. 1984 Review Vitamin D metabolism and chronic liver disease.Wills MR Savory J. Ann Clin Lab Sci. 1984 May-Jun 14(3)189-97. Review Main endocrine modulators of vitamin D hydroxylases in human pathophysiology. J Steroid Biochem. 1987 Review Main endocrine modulators of vitamin D hydroxylases in human pathophysiology.Caniggia A Lorè F di Cairano G Nuti R. J Steroid Biochem. 1987 27(4-6)815-24. Review Metabolism and action of the hormone vitamin D. Its relation to diseases of calcium homeostasis. West J Med. 1974 Review Metabolism and action of the hormone vitamin D. Its relation to diseases of calcium homeostasis.Coburn JW Hartenbower DL Norman AW. West J Med. 1974 Jul 121(1)22-44. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant with the “linked from” citation displayed first. Compound (MeSH Keyword) PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Substance (MeSH Keyword) PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles. Recent activity Clear Turn Off Turn On Vitamin D metabolism. Vitamin D metabolism.Endocrinol Metab Clin North Am. 2010 Jun 39(2)243-53 table of contents. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more... 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